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No Amphibole Exposure

C. cases of Mesothelioma in Cohorts Where No Amphibole Exposure Was Identified Do Not Demonstrate Chrysotile Is The Cause (Table 3)

The number of mesothelioma cases is very low or zero in all cohorts exposed to chrysotile asbestos that is not known to be contaminated by amphibole fibers. There are 14 identified cohort studies describing exposures solely to chrysotile asbestos. Of approximately 32,000 subjects, only 7 mesothelioma cases are reported, and each case probably had exposure to amphiboles, inaccurate diagnosis, and/or insufficient latency periods (Table 4). The levels of exposures in the studies do not differ substantially from those listed in Tables 1 and 2, given the limitations and heterogeneity of this data.